International Circulation: What is the difference between the Nevo stent and the Cypher stent? What are some of the design innovations? Prof. Spaulding: There are several innovations. The first innovation is the platform. The platform is a chromium/cobalt platform that is an open-cell thin strut design. Therefore it is very flexible and will be easier to deliver compared to the Cypher stent. The two other new features on the stent are reservoir technology and the use of a biodegradable polymer. The advantage of the biodegradable polymer is that the polymer and the drug are embedded in the stent and therefore there is a reduction of the contact between the polymer and the surface and therefore in animal studies it reduces inflammation and could potentially reduce stent thrombosis in clinical trials. The other new feature is a biodegradable polymer that is completely absorbed after 3~4 months. In animal studies there has been less inflammation and therefore it is potentially a source of a reduction of stent thrombosis. Those are the differences.

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